Quickest 2h 31min
There are 4 buses1 train company operating 5 routes - ICE50, ICE11, ICE12, ICE43, RE17, 1 flight from Wiesbaden to Kassel. The cheapest train costs $58 and is 5h 54min.
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There are 4 ways to travel from Wiesbaden to Kassel. 4 buses, 2 trains, 1 flight and 1 by car are possible between the two areas. The by car from Wiesbaden to Kassel is the cheapest. The by car from Wiesbaden to Kassel is the fastest. The train operated by running from Wiesbaden to Kassel is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!