Quickest 7h 38min
There are 3 buses1 train company operating 2 routes - Silver Star, Maple Leaf, and 3 flights from Syracuse to Cape Coral. The cheapest train costs $225 and is 1d 3h 5min.
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There are 4 ways to travel from Syracuse to Cape Coral. 3 buses, 4 trains, 3 flights and 1 by car are possible between the two areas. The by car from Syracuse to Cape Coral is the cheapest. The flight from BGM to RSW is the fastest. The train operated by Amtrak running from SYR to SBG is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!