Quickest 7h 32min
There are 1 train company operating 2 routes - Empire Builder, City Of New Orleans, 3 flights and 3 buses from SPL to HMD. The cheapest train costs $232 and is 1d 4h 3min.
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There are 4 ways to travel from SPL to HMD. 4 trains, 3 flights, 3 buses and 1 by car are possible between the two areas. The by car from SPL to HMD is the cheapest. The flight from STC to MSY is the fastest. The train operated by Amtrak running from SPL to HMD is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!