Quickest 2h 39min
There are 1 flight 4 buses1 train company operating 3 routes - R-20, R-1, C-7 from SLM to MAD. The cheapest train costs $31 and is 4h 14min.
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There are 4 ways to travel from SLM to MAD. 1 flight, 4 buses, 1 train and 1 by car are possible between the two areas. The by car from SLM to MAD is the cheapest. The by car from SLM to MAD is the fastest. The train operated by Renfe running from San Morales to Madrid-Ramón y Cajal is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!