Quickest 4h 42min
There are 4 buses1 train company operating 5 routes - RE1, IC26, ICE28, ICE12, CNL 1258 from Schleiz to Karlsruhe. The cheapest train costs $100 and is 5h 52min.
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There are 3 ways to travel from Schleiz to Karlsruhe. 4 buses, 2 trains and 1 by car are possible between the two areas. The by car from Schleiz to Karlsruhe is the cheapest. The by car from Schleiz to Karlsruhe is the fastest. The train operated by running from Weida to Karlsruhe is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!