Quickest 3h 26min
There are 2 ferry companies operating from Santorini to Piraeus, 3 flights from Santorini to Piraeus. The cheapest ferry costs $87 and is 3h 30min.
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There are 2 ways to travel from Santorini to Piraeus. 4 ferries and 3 flights are possible between the two areas. The ferry operated by Sea Jets running from Folegandros to Piraeus is the cheapest. The ferry operated by Hellenic Seaways running from Thira (Santorini) to Piraeus is the fastest. The ferry operated by Hellenic Seaways running from Thira (Santorini) to Piraeus is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!