Quickest 1h 35min
There are 3 ferry companies operating from Piraeus to Thira (Santorini), 3 flights from Piraeus to Thira (Santorini). The cheapest ferry costs $100 and is 5h 49min.
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There are 2 ways to travel from Piraeus to Thira (Santorini). 4 ferries and 3 flights are possible between the two areas. The ferry operated by Sea Jets running from Rafina to Thira (Santorini) is the cheapest. The ferry operated by Anek Lines running from Piraeus to Anafi is the fastest. The ferry operated by Ventouris Sea Lines running from Piraeus to Thira (Santorini) is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!