Quickest 6h 12min
There are 4 buses 4 flights1 train company operating 2 routes - Cardinal, Silver Star from Ocean City to Lafayette. The cheapest train costs $125 and is 13h 51min.
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There are 4 ways to travel from Ocean City to Lafayette. 4 buses, 4 flights, 4 trains and 1 by car are possible between the two areas. The by car from Ocean City to Lafayette is the cheapest. The flight from SBY to IND is the fastest. The train operated by Amtrak running from WIL to LAF is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!