Quickest 2h 57min
There are 1 flight1 train company operating 5 routes - ICE41, CNL 1258, ICE28, ICE42, ICE25, and 4 buses from NUE to FRA. The cheapest train costs $35 and is 3h 20min.
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There are 4 ways to travel from NUE to FRA. 1 flight, 3 trains, 4 buses and 1 by car are possible between the two areas. The by car from NUE to FRA is the cheapest. The by car from NUE to FRA is the fastest. The train operated by DB running from Nuremberg to Kelsterbach is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!