Quickest 7h 28min
There are 4 buses1 train company operating 3 routes - Acela Express, Silver Star, Shuttle, and 3 flights from New London to Saint Petersburg. The cheapest train costs $211 and is 1d 1h 13min.
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There are 4 ways to travel from New London to Saint Petersburg. 4 buses, 3 trains, 3 flights and 1 by car are possible between the two areas. The by car from New London to Saint Petersburg is the cheapest. The flight from HVN to TPA is the fastest. The train operated by Amtrak running from NLC to TPA is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!