Quickest 7h 22min
There are 3 buses1 train company operating 3 routes - Texas Eagle, Hiawatha Service, Empire Builder, and 3 flights from Milwaukee to San Antonio. The cheapest train costs $210 and is 1d 1h 1min.
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There are 4 ways to travel from Milwaukee to San Antonio. 3 buses, 3 trains, 3 flights and 1 by car are possible between the two areas. The by car from Milwaukee to San Antonio is the cheapest. The flight from MKE to AUS is the fastest. The train operated by Amtrak running from MKE to SAS is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!