Quickest 2h 45min
There are 4 buses1 flight1 train company operating 4 routes - AVE, C-10, C-2, R-1 from Medina de Ríoseco to Madrid. The cheapest train costs $44 and is 2h 45min.
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There are 4 ways to travel from Medina de Ríoseco to Madrid. 4 buses, 1 flight, 1 train and 1 by car are possible between the two areas. The by car from Medina de Ríoseco to Madrid is the cheapest. The train operated by Renfe running from Valladolid to Madrid is the fastest. The train operated by running from Valladolid to Madrid is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!