Quickest 3h 11min
There are 2 buses1 train company operating 4 routes - 905 000, TER 63/15, TER 13, TER 62 from Marseille to Grenoble. The cheapest train costs $37 and is 3h 11min.
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There are 3 ways to travel from Marseille to Grenoble. 2 buses, 1 train and 1 by car are possible between the two areas. The by car from Marseille to Grenoble is the cheapest. The train operated by SNCF running from Marseille St-Antoine to Jarrie—Vizille is the fastest. The train operated by SNCF running from Marseille to Grenoble is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!