The are 3 different ways across 3 unique modes of transportation to help you travel from Mainaschaff to Frankfurt am Main. The fastest way out of Aschaffenburg towards Frankfurt am Main is by bus, as it is the quickest to the Frankfurt am Main area. This doesn't necessarily take into consideration traffic or weather - so these may impact some of your decision making. It's common to find tickets for as low as $13. DB operates from Mainaschaff to Frankfurt am Main, so you book your trip with them! Book as soon as you can, as there may be limited availability.
The earlier you can book your trip to Frankfurt am Main, the better. There is usually no need to book these sort of trips from Mainaschaff to Frankfurt am Main in advance. Rideshares should be available on demand all hours of the day.
While buses have recently gotten bad coverage because of cleanliness of bus stations or winter time accidents, they are can be very convenient for travel. The best part about traveling by bus to Frankfurt am Main is that it can be very cheap. That's because they usually have basic accomodations - WiFi and a restroom. Some of the Mainaschaff/Frankfurt am Main buses' coverage has been overstated. The real thing to consider when taking a bus from Mainaschaff is to consider the time of travel and the density of the cities that you're traveling to. If you are traveling by bus between Mainaschaff Bavaria and Frankfurt am Main during high traffic times, you can expect to have your trip altered significantly due to traffic. Further, if you are traveling during winter, the bus schedule might be thrown off due to inclimate winter weather. Be sure to plan accordingly!
The plus side of taking the train from Mainaschaff to Frankfurt am Main? The accomodations, scenery, and lack of Frankfurt am Main traffic can usually be on point. Moreover, you can usually expect your average concessions - such as food and drinks. Most trains have WiFi these days as well. The worst part about trains are the price. While the train to Frankfurt am Main is often cheaper than flying, they are generally more expensive than buses. Train prices are usually set and do not vary as much as bus prices or flights or so the likelihood of finding discounts is pretty rare.