Quickest 2h 34min
There are 1 train company operating 3 routes - Línea 77, C-2, C-3, 4 buses from Madrid to Villahermosa. The cheapest train costs $42 and is 2h 34min.
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There are 3 ways to travel from Madrid to Villahermosa. 1 train, 4 buses and 1 by car are possible between the two areas. The by car from Madrid to Villahermosa is the cheapest. The train operated by Renfe running from Aranjuez to Valdepeñas is the fastest. The train operated by running from Madrid to Valdepeñas is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!