Quickest 2h 23min
There are 1 train company operating 2 routes - Línea 77, C-3, 4 buses from Madrid to Santa Cruz de Mudela. The cheapest train costs $43 and is 2h 45min.
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There are 3 ways to travel from Madrid to Santa Cruz de Mudela. 1 train, 4 buses and 1 by car are possible between the two areas. The by car from Madrid to Santa Cruz de Mudela is the cheapest. The train from Madrid to Manzanares is the fastest. The train operated by Renfe running from Madrid Atocha to Santa Cruz de Múdela is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!