Quickest 7h 23min
There are 3 buses 3 flights1 train company operating 2 routes - California Zephyr, Cardinal from Lexington to Fort Collins. The cheapest train costs $221 and is 1d 2h 29min.
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There are 4 ways to travel from Lexington to Fort Collins. 3 buses, 3 flights, 4 trains and 1 by car are possible between the two areas. The by car from Lexington to Fort Collins is the cheapest. The flight from SDF to CYS is the fastest. The train operated by Amtrak running from MAY to DEN is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!