Quickest 4h 7min
There are 4 buses1 train company operating 3 routes - S1, ICN 5, IC 7 from Leutkirch to Lausanne. The cheapest train costs $44 and is 4h 34min.
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There are 3 ways to travel from Leutkirch to Lausanne. 4 buses, 2 trains and 1 by car are possible between the two areas. The by car from Leutkirch to Lausanne is the cheapest. The train from Rheineck to Renens is the fastest. The train operated by running from St-Margrethen to Lausanne is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!