Quickest 7h 28min
There are 4 buses3 flights1 train company operating 2 routes - California Zephyr, Cardinal from Ledyard to Des Moines. The cheapest train costs $199 and is 23h 38min.
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There are 4 ways to travel from Ledyard to Des Moines. 4 buses, 3 flights, 3 trains and 1 by car are possible between the two areas. The by car from Ledyard to Des Moines is the cheapest. The flight from ISP to DSM is the fastest. The train operated by Amtrak running from NYP to OSC is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!