Quickest 7h 30min
There are 3 buses1 train company operating 2 routes - Silver Star, Acela Express, and 3 flights from Kissimmee to Barnstable. The cheapest train costs $213 and is 1d 1h 30min.
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There are 4 ways to travel from Kissimmee to Barnstable. 3 buses, 3 trains, 3 flights and 1 by car are possible between the two areas. The by car from Kissimmee to Barnstable is the cheapest. The flight from MCO to MVY is the fastest. The train operated by Amtrak running from KIS to RTE is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!