Quickest 2h 47min
There are 4 buses1 train company operating 2 routes - IC26, ICE12 from Karlsruhe to Gladenbach. The cheapest train costs $72 and is 2h 47min.
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There are 3 ways to travel from Karlsruhe to Gladenbach. 4 buses, 2 trains and 1 by car are possible between the two areas. The by car from Karlsruhe to Gladenbach is the cheapest. The train operated by DB running from Karlsruhe to Lollar is the fastest. The train operated by DB running from Karlsruhe Mühlburger Tor to Niederweimar is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!