Quickest 7h 29min
There are 1 train company operating 3 routes - Acela Express, Silver Star, Shuttle, 3 flights and 3 buses from HOL to STM. The cheapest train costs $210 and is 1d 1h 5min.
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There are 4 ways to travel from HOL to STM. 4 trains, 3 flights, 3 buses and 1 by car are possible between the two areas. The by car from HOL to STM is the cheapest. The flight from FLL to LGA is the fastest. The train operated by Amtrak running from HOL to NRO is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!