Quickest 2h 48min
There are 4 buses1 train company operating 2 routes - ICE20, IC26 from Gladenbach to Karlsruhe. The cheapest train costs $72 and is 2h 48min.
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There are 3 ways to travel from Gladenbach to Karlsruhe. 4 buses, 2 trains and 1 by car are possible between the two areas. The by car from Gladenbach to Karlsruhe is the cheapest. The train operated by DB running from Friedelhausen to Karlsruhe Bahnhofsvorplatz is the fastest. The train operated by DB running from Niederweimar to Karlsruhe Marktplatz (Kaiserstraße) is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!