Quickest 3h 5min
There are 4 buses1 train company operating 4 routes - ICE41, ICE42, ICE11, RE3, 1 flight from Frankfurt am Main to Oberhausen. The cheapest train costs $36 and is 3h 30min.
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There are 4 ways to travel from Frankfurt am Main to Oberhausen. 4 buses, 3 trains, 1 flight and 1 by car are possible between the two areas. The by car from Frankfurt am Main to Oberhausen is the cheapest. The by car from Frankfurt am Main to Oberhausen is the fastest. The train operated by DB running from Frankfurt (Main) Süd to Oberhausen Hbf is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!