Quickest 2h 33min
There are 1 flight1 train company operating 2 routes - ICE43, RE17, and 4 buses from FRA to KSF. The cheapest train costs $103 and is 5h 2min.
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There are 4 ways to travel from FRA to KSF. 1 flight, 3 trains, 4 buses and 1 by car are possible between the two areas. The by car from FRA to KSF is the cheapest. The by car from FRA to KSF is the fastest. The train operated by running from Kelsterbach to Grebenstein is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!