Quickest 2h 2min
There are 2 train companies operating 7 routes - ICE41, ICE11, S1, IC62, ICE42, ICE82, RE11, 4 buses1 flight from Duisburg to Frankfurt am Main. The cheapest train costs $30 and is 2h 2min.
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There are 4 ways to travel from Duisburg to Frankfurt am Main. 4 trains, 4 buses, 1 flight and 1 by car are possible between the two areas. The by car from Duisburg to Frankfurt am Main is the cheapest. The train operated by DB running from Duisburg to Frankfurt (M) Galluswarte is the fastest. The train operated by running from Duisburg to Frankfurt (M) Galluswarte is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!