Quickest 4h 59min
There are 4 buses1 train company operating 3 routes - TGV 522, FR-830, TGV 505 from Colmar to Lyon. The cheapest train costs $54 and is 5h 42min.
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There are 3 ways to travel from Colmar to Lyon. 4 buses, 2 trains and 1 by car are possible between the two areas. The by car from Colmar to Lyon is the cheapest. The by car from Colmar to Lyon is the fastest. The train operated by running from Bantzenheim to Lyon is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!