Quickest 7h 32min
There are 4 buses1 train company operating 2 routes - Silver Star, Maple Leaf, and 3 flights from Buffalo to Port Charlotte. The cheapest train costs $245 and is 1d 5h 43min.
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There are 4 ways to travel from Buffalo to Port Charlotte. 4 buses, 3 trains, 3 flights and 1 by car are possible between the two areas. The by car from Buffalo to Port Charlotte is the cheapest. The flight from BUF to SRQ is the fastest. The train operated by Amtrak running from BFX to SBG is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!