Quickest 7h 35min
There are 4 buses3 flights1 train company operating 2 routes - Maple Leaf, Silver Star from Port Charlotte to Ithaca. The cheapest train costs $225 and is 1d 3h 5min.
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There are 4 ways to travel from Port Charlotte to Ithaca. 4 buses, 3 flights, 3 trains and 1 by car are possible between the two areas. The by car from Port Charlotte to Ithaca is the cheapest. The flight from RSW to ELM is the fastest. The train operated by Amtrak running from SBG to SYR is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!