Quickest 2h 44min
There are 1 flight1 train company operating 4 routes - RE1, ICE43, ICE42, ICE41, 4 buses from PAD to FRA. The cheapest train costs $48 and is 5h 9min.
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There are 4 ways to travel from PAD to FRA. 1 flight, 2 trains, 4 buses and 1 by car are possible between the two areas. The by car from PAD to FRA is the cheapest. The by car from PAD to FRA is the fastest. The train operated by running from Salzkotten to Kelsterbach is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!