Quickest 3h 5min
There are 4 buses2 train companies operating 6 routes - ICE41, ICE11, S1, RE3, ICE12, ICE42, 1 flight from Oberhausen to Frankfurt am Main. The cheapest train costs $36 and is 3h 27min.
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There are 4 ways to travel from Oberhausen to Frankfurt am Main. 4 buses, 3 trains, 1 flight and 1 by car are possible between the two areas. The by car from Oberhausen to Frankfurt am Main is the cheapest. The by car from Oberhausen to Frankfurt am Main is the fastest. The train operated by DB running from Oberhausen Hbf to Frankfurt (M) Taunusanlage is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!