There are 1 train company operating 4 routes - AVE, C-10, C-2, R-1. The cheapest train costs $45 and is 2h 45min.
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There are 4 ways to travel from Medina de Ríoseco to Madrid. 4 buses, 1 flight, 1 train and 1 by car are possible between the two areas. The by car from Medina de Ríoseco to Madrid is the cheapest and fastest. The train operated by running from Valladolid to Madrid is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!