There are 1 train company operating 2 routes - RE17, ICE43. The cheapest train costs $104 and is 5h 1min.
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There are 4 ways to travel from KSF to FRA. 1 flight, 3 trains, 4 buses and 1 by car are possible between the two areas. The by car from KSF to FRA is the cheapest and fastest. The train operated by running from Grebenstein to Kelsterbach is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!