There are 1 train company operating 2 routes - IC26, IC77. The cheapest train costs $108 and is 6h 22min.
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There are 3 ways to travel from Giessen to Enschede. 4 buses, 2 trains and 1 by car are possible between the two areas. The by car from Giessen to Enschede is the cheapest and fastest. The train operated by running from Gießen to Hengelo is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!