Quickest 4h 49min
There are 2 train companies operating 2 routes - ICE82, 9300 from Frankfurt am Main to Brussels. The cheapest train costs $78 and is 11h 53min.
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There are 4 ways to travel from Frankfurt am Main to Brussels. 4 buses, 3 trains, 2 flights and 1 by car are possible between the two areas. The by car from Frankfurt am Main to Brussels is the cheapest. The flight from FRA to BRU is the fastest. The train operated by running from Frankfurt am Main to Brussels is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!