Quickest 2h 46min
There are 1 flight1 train company operating 3 routes - ICE12, ICE10, ICE42, 4 buses from FRA to DTM. The cheapest train costs $86 and is 3h 59min.
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There are 4 ways to travel from FRA to DTM. 1 flight, 3 trains, 4 buses and 1 by car are possible between the two areas. The by car from FRA to DTM is the cheapest. The by car from FRA to DTM is the fastest. The train operated by running from Kelsterbach to Holzwickede is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!