Quickest 5h 6min
There are 4 buses1 train company operating 2 routes - Crescent, Silver Star, 4 flights from Columbia to Columbus. The cheapest train costs $250 and is 1d 6h 25min.
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There are 4 ways to travel from Columbia to Columbus. 4 buses, 4 trains, 4 flights and 1 by car are possible between the two areas. The by car from Columbia to Columbus is the cheapest. The flight from CAE to MCN is the fastest. The train operated by Amtrak running from CLB to ATN is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!