There are 3 train companies operating 5 routes - ICE10, MRB32, IC55, ICE50, SE10. The cheapest train costs $88 and is 4h 41min.
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There are 3 ways to travel from Bielefeld to Mainz. 4 buses, 1 train and 1 driving option are possible between the two areas. The driving option from Bielefeld to Mainz is the cheapest. The driving option from Bielefeld to Mainz is the fastest. The train operated by running from Bielefeld to Mainz is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!