Quickest 5h 47min
There are 3 train companies operating 4 routes - IC77, 9300, 9200, RB 33 from Berlin to Brussels. The cheapest train costs $51 and is 9h 30min.
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There are 4 ways to travel from Berlin to Brussels. 2 buses, 4 trains, 2 flights and 1 by car are possible between the two areas. The by car from Berlin to Brussels is the cheapest. The flight from TXL to BRU is the fastest. The train operated by running from Berlin to Bruxelles-Midi Eurostar is the most convenient.
It's important to check each mode when booking your ticket so that you can find the best method for you. The cost of each type varies differently, so be sure to use Faretrotter to keep an eye out!